Endocrine Abstracts

Background: Medullary thyroid cancer (MTC) is a rare malignancy with a variable and sometimes unpredictable disease course. To predict the course of disease more accurately at diagnosis, we introduce dynamic risk stratification by analyzing factors related to “stage migration” within the first 5 years after diagnosis.Methods: All patients diagnosed at the University Medical Center of Groningen between 1999 and 2015 were retrospectively studied....

Background: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor derived from the parafollicular C-cells of the thyroid gland. Mutations in the gene encoding the Rearranged during Transfection (RET) tyrosine kinase, play a vital role in the development of MTCs. In patients with distant metastases, only targeted therapy can prolong survival. Tyrosine kinase inhibitors (TKIs) block tyrosine kinases such as RET and thereby inhibit tumor proliferation. However, it is diffic...